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KMID : 0861020120270030023
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Korea Journal of Herbology
2012 Volume.27 No. 3 p.23 ~ p.29
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Anti-microbial Effect on Streptococcus mutans and Anti-oxidant Effect of the Butanol Fractions of Sanguisorbae Radix
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Park Gun-Hye
Lee Jin-Tae
An Bong-Jeun
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Abstract
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Objective: Sanguisorbae Radix(SO). that belong to Rosaceae is widely distributed in Asia including Korea,
Japan and China. It has been used as traditional medicine from old times as a treatment for anti-inflammatory
drugs. This study was designed to investigate the effects of n-BuOH fractions of SO on anti-oxidant effect
and anti-microbial effect on Streptococcus mutans (S. mutans).
Methods: The anti-microbial effect of n-BuOH fractions of SO. was assessed by the paper disk diffusion
method and anti-oxidant effect was assessed by the DPPH radical scavenging effect, Superoxide anion radical
scavenging effect and SOD like ability.
Results: DPPH radical scavenging of the n-BuOH fraction from SO in 50 ug/mL was shown to be Fr-2
(89.9%), Fr-3 (88.7%), Fr-4 (76.3%), Fr-1 (59.4%), Fr-5 (56.2%). Superoxside anion radical scavenging activity
of the n-BuOH fraction from SO. in 50 ug/mL for Fr-3 was shown to be 78%. SOD-like activity of n-BuOH
fraction from the SO in 1000 ug/mL for Fr-3 were shown to be 76.1% respectively. The n-BuOH fraction from
the SO had high anti-microbial effect on S. mutans.
Conclusion: As a result, the n-BuOH fraction from SO. has good anti-microbial and anti-oxidant effects in a
concentration-dependent manner.
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KEYWORD
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Sanguisorbae Radix, anti-oxidant, anti-microbial
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